Given the wide range of actors supporting efforts to improve women’s, children’s and adolescents’ health, effective coordination of quality Technical Assistance (TA) at global, regional and country level to support operationalization of the Global Strategy, and the development, implementation and monitoring of RMNCAH investment cases and plans is essential. This paper will focus on the alignment, harmonization and coordination of global TA in support to country’s efforts to develop and implement the RMNCH investment cases while building the local capacities. It summarizes key areas of TA support, outlines modalities and suggests options for mechanisms of coordination of TA at the global level.