This document responds to a request by the GFF’s Investors Group (IG), and will be discussed at the IG meeting. It aims to clarify mandates, common principles, and approaches, and proposes concrete areas for intensified collaboration across the three organizations, Gavi, the Vaccine Alliance (Gavi), the Global Financing Facility, and the Global Fund. It builds on ongoing discussions and collaboration at both leadership and operational levels between the three organizations. The paper addresses issues relevant to a sub-group of institutions in the global health architecture and does not aim to replace the SDG3 Action Plan1 collaboration discussions, which all three are party to.